团队一览

以科学高于一切为宗旨,组建强大的肿瘤研究团队,结合引进科学家的学术背景和兴趣,对肿瘤核心科学和临床核心问题集中力量攻关。

Justin L. Tan

特聘研究员

联系方式:justin.tan@szbl.ac.cn

研究方向

  • 长期从事使用先进化学生物技术发现天然产物与合成化合物抑制谱系转录因子癌基因,并最终实现创新先进癌症药物的开发
  • 通过建立并研究工程细胞系和人源肿瘤异体移植模型,描述谱系转录因子在促进肿瘤发生和细胞分化中的作用机制

  • 开发并结合高通量筛选技术来鉴定肿瘤形成相关的化学抑制剂,以研究谱系因子在肿瘤形成过程中对细胞命运的调节机制


荣誉

  • National Science Scholarship (Singapore)

  • 100 Global Young Scientific Leaders (Gap Summit)

  • Certificate of Distinction in Teaching (Harvard)

研究方向-示图

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历程

  • 2020-Present
    Shenzhen Bay Laboratory    Principal Investigator
  • 2017-2020

    Genome Institute of Singapore    Junior Principal Investigator

  • 2015-2020
    Cancer Science Institute, NUS    Research Fellow
  • 2014-2015
    Boston Children’s Hospital    Postdoctoral Fellow
  • 2009-2014

    Harvard University    Ph.D. in Chemical Biology

  • 2008-2009
    Genome Institute of Singapore    Research Officer
  • 2005-2008
     University of California, Los Angeles    B.Sc. in Biochemistry

研究成果

Justin's work has been published in high impact journals such as Molecular Cell, Science, and Gastroenterology. He is an inventor on a patent for novel cancer therapeutics. Justin had received nearly 5,000,000 RMB of grants while he was a Junior Principal Investigator in Singapore. He is a member of the American Association for Cancer Research.

代表性研究成果

Tenen DG, Chai L & Tan JL*. Metabolic alterations and vulnerabilities in hepatocellular carcinoma. Gastroenterology Report, doi.org/10.1093/gastro/goaa066 (2020). *Corresponding author. [Invited review article]

Tan JL*, Li F, Yeo JZ, Yong KJ, Bassal MA, Ng GH, Lee MY, Leong CY, Tan HK, Wu CS, Liu BH, Chan TH, Tan ZH, Chan YS, Wang S, Lim ZH, Toh TB, Hooi L, Low KN, Ma S, Kong NR, Stein AJ, Wu Y, Thangavelu MT, Suzuki A, Periyasamy G, Asara JM, Dan YY, Bonney GK, Chow EK, Lu G, Ng HH, Kanagasundaram Y, Ng SB, Tam WL, Tenen DG & Chai L. New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation. Gastroenterology 157, 1615 (2019). *Co-corresponding author. [Editorial Highlight in Gastroenterology]

Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA & Zon LI. Stress from nucleotide depletion activates the transcriptional regulator HEXIM1 to suppress melanoma. Mol. Cell 62, 34-46 (2016). [Highlighted in News and Views in Pigment Cell & Melanoma Research]

Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science 351, 464 (2016).

Tan JL & Zon LI. Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol. 105, 493-516 (2011).