联系方式:justin.tan@szbl.ac.cn
通过建立并研究工程细胞系和人源肿瘤异体移植模型,描述谱系转录因子在促进肿瘤发生和细胞分化中的作用机制
开发并结合高通量筛选技术来鉴定肿瘤形成相关的化学抑制剂,以研究谱系因子在肿瘤形成过程中对细胞命运的调节机制
National Science Scholarship (Singapore)
100 Global Young Scientific Leaders (Gap Summit)
Certificate of Distinction in Teaching (Harvard)
Genome Institute of Singapore Junior Principal Investigator
Harvard University Ph.D. in Chemical Biology
Tenen DG, Chai L & Tan JL*. Metabolic alterations and vulnerabilities in hepatocellular carcinoma. Gastroenterology Report, doi.org/10.1093/gastro/goaa066 (2020). *Corresponding author. [Invited review article]
Tan JL*, Li F, Yeo JZ, Yong KJ, Bassal MA, Ng GH, Lee MY, Leong CY, Tan HK, Wu CS, Liu BH, Chan TH, Tan ZH, Chan YS, Wang S, Lim ZH, Toh TB, Hooi L, Low KN, Ma S, Kong NR, Stein AJ, Wu Y, Thangavelu MT, Suzuki A, Periyasamy G, Asara JM, Dan YY, Bonney GK, Chow EK, Lu G, Ng HH, Kanagasundaram Y, Ng SB, Tam WL, Tenen DG & Chai L. New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation. Gastroenterology 157, 1615 (2019). *Co-corresponding author. [Editorial Highlight in Gastroenterology]
Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA & Zon LI. Stress from nucleotide depletion activates the transcriptional regulator HEXIM1 to suppress melanoma. Mol. Cell 62, 34-46 (2016). [Highlighted in News and Views in Pigment Cell & Melanoma Research]
Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science 351, 464 (2016).
Tan JL & Zon LI. Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol. 105, 493-516 (2011).