联系方式：yincq@szbl.ac.cn
课题组主要从事癌症发生和发展的机制研究以及针对癌症预防和治疗的药物干预方法开发。课题组将运用前沿的分子生物学、肿瘤生物学和基因编辑技术，结合临床样本分析和基因修饰小鼠模型，揭示癌症驱动蛋白参与的关键信号转导途径，以及开发癌症预防和治疗的新靶点、新药物和治疗新手段。
美国国立卫生研究院Pathway to Independence Award
美国癌症研究协会 Scholar-in-Training Award
德雷塞尔大学 Teck-Kah Lim 研究生奖
中国科学技术大学优秀学生奖学金
Yin, C*; Zhu, B*; Zhang, T*; Liu, T*; Chen, S; Liu, Y; Li, X; Miao, X; Li, S; et al. Pharmacological targeting of STK19 inhibits oncogenic NRAS-driven melanomagenesis. Cell, 2019 Feb 21; 176(5):1113-1127.
Chen, S*; Zhu, B*; Yin, C*; Liu, W; Han, C; Chen, B; Liu, T; Li, X; Chen, X; Li, C; et al. Palmitoylation-dependent activation of MC1R prevents melanomagenesis. Nature, 2017 Sep 21; 549(7672):399-403. (*Co-first author)
Zhu, B*; Chen, S*; Wang, H*; Yin, C*; Han, C*; Peng, C; Liu, Z; Wan, L; et al. The protective role of DOT1L in UV-induced melanomagenesis. Nature Communications, 2018 Jan 17; 9(1):259. (*Co-first author)
Zhu, B*; Tang, L*; Chen, S*; Yin, C*; Peng, S; Li, X; Liu, T; Liu, W; Han, C; et al. Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy. Oncogene, 2018 Sep; 37(36):4941-4954. (*Co-first author)
Chen, S; Han, C; Miao, X; Li, X; Yin, C; Zou, J; Liu, M; Li, S; Stawski, L; Zhu, B; et al. Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads. Nature Communications, 2019 Feb 20; 10(1):877.
