Team Overview

With the notion of science above everything else, a strong tumor research team has been formed, combined with the academic background and interests of the scientists, and concentrated on tackling key tumor science and clinical core issues.

Chengqian Yin

Junior Principal Investigator

Email: yincq@szbl.ac.cn

Research Areas

My research focuses on the regulation of signal transduction pathways mediated by protein post-translational modifications in malignant tumors such as melanoma, with an emphasis on exploring the mechanical role of signal transduction in driving the initiation and development of cancer, the discovery of new drug targets and the development of novel small molecule inhibitors.


Honors


  • 2020,Pathway to Independence Awards (K99/R00), National Institutes of Health
  • 2016,Bristol-Myers Squibb Oncology Scholar-in-Training Award, American Association for Cancer Research
  • 2016,TECK-KAH LIM Graduate Student Award, Drexel University
  • 2014,TECK-KAH LIM Graduate Student Award, Drexel University


Pictorial View

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Timeline

  • 2020 - Present
    Junior Principal Investigator,Shenzhen Bay Laboratory
  • 2020.04 - 2020.09
    Research Fellow,Massachusetts General Hospital
  • 2016 - 2020
    Research Scientist ,Boston University School of Medicine
  • 2010 - 2016
    PhD,Drexel University 
  • 2006-2010
    Bachelor,University of Science and Technology of China 

Highlights

To explore intervention opportunities for prevention and treatment of melanoma, I have conducted in-depth research on the initiation and development of melanoma in recent years,  and have achieved a series of research accomplishments with important academic value and clinical translational potential. So far, I have published a total of 19 professional academic papers in research fields of signal transduction and melanoma biology, of which 6 were published as the first (including co-first) author in internationally renowned journals such as Cell, Nature, and Nature Communications.


We explained the molecular mechanism of the G protein-coupled receptor MC1R being palmitoylated to suppress the occurrence of melanoma, and developed a pharmaceutical method to prevent the occurrence of melanoma (Nature, 2017). We also revealed serine/threonine kinase STK19 promotes the molecular mechanism of melanoma development through phosphorylation of NRAS, and developed a novel specific small molecule inhibitor that significantly inhibits the development of melanoma (Cell, 2019). I have applied for one U.S. patent and obtained two Chinese patent authorizations. Based on my previous research, I have won the Bristol-Myers Squibb Oncology Scholar-in-Training Award issued by the American Association for Cancer Research (AACR) in 2016, and received a research funding from the National Institutes of Health (NIH) as the sole principal investigator (PI) in 2020 as the K99/R00 NIH Pathway to Independence Award.

Selected Publications

Yin, C*; Zhu, B*; Zhang, T*; Liu, T*; Chen, S; Liu, Y; Li, X; Miao, X; Li, S; et al. Pharmacological targeting of STK19 inhibits oncogenic NRAS-driven melanomagenesis. Cell, 2019 Feb 21; 176(5):1113-1127.

Chen, S*; Zhu, B*; Yin, C*; Liu, W; Han, C; Chen, B; Liu, T; Li, X; Chen, X; Li, C; et al. Palmitoylation-dependent activation of MC1R prevents melanomagenesis. Nature, 2017 Sep 21; 549(7672):399-403. (*Co-first author)

Zhu, B*; Chen, S*; Wang, H*; Yin, C*; Han, C*; Peng, C; Liu, Z; Wan, L; et al. The protective role of DOT1L in UV-induced melanomagenesis. Nature Communications, 2018 Jan 17; 9(1):259. (*Co-first author)

Zhu, B*; Tang, L*; Chen, S*; Yin, C*; Peng, S; Li, X; Liu, T; Liu, W; Han, C; et al. Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy.Oncogene, 2018 Sep; 37(36):4941-4954. (*Co-first author)

Chen, S; Han, C; Miao, X; Li, X; Yin, C; Zou, J; Liu, M; Li, S; Stawski, L; Zhu, B; et al. Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads. Nature Communications, 2019 Feb 20; 10(1):877.