Email: xglei@pku.edu.cn
Our lab focused on the design, synthesis, and evaluation of anti-cancer chemical small molecules by comprehensive utilization of various approaches including high throughput screening, organic synthesis, chemical biology, cell biology, molecular genetics, and molecular pharmacology, aiming to development of innovative anti-cancer drugs targeting transcription factors.
Xiaoguang Lei is a professor in the College of Chemistry and Molecular Engineering at Peking University, senior investigator at Peking-Tsinghua Center for Life Sciences, winner of National Distinguished Young Investigator Award, and 973 chief scientist.
Prof. Lei is a world-renowned organic synthetic chemist, chemical biologist, and pharmaceutical chemist, and has made a series of original scientific achievements in the fields of natural product function-oriented total synthesis, chemical biology, synthetic biology, and innovative drug development. He has published more than 80 papers in Cell, Nature, Science, and other journals, and obtained more than 10 patents of innovative drug invention. To date, two candidate drug molecules of them have achieved scientific research transformation, and clinical research will be carried out soon. He has won 18 academic awards at home and abroad, including Tetrahedron Young Investigator Award in Bioorganic and Medicinal Chemistry, Young Chemical Biologist Award by the International Chemical Biology Society (ICBS), Shulan Medical Youth Award, CCS-BASF Young Investigator Award, Wei Shan Natural Product Synthesis Award by Chinese Chemical Society, IUPAC Young Chemist Award, and Servier Young Investigator Award by Chinese Pharmaceutical Association. Currently, Prof. Lei is an executive chief editor of the international pharmaceutical core journal《Bioorganic & Medicinal Chemistry》.
Lei Gao, Cong Su, Xiaoxia Du, Ruishan Wang, Shuming Chen, Yu Zhou, Chengwei Liu, Xiaojing Liu, Runze Tian, Liyun Zhang, Kebo Xie, She Chen, Qianqian Guo, Lanping Guo, Yoshio Hano, Manabu Shimazaki, Atsushi Minami, Hideaki Oikawa, Niu Huang, K. N. Houk, Luqi Huang*, Jungui Dai*, Xiaoguang Lei* "FAD-dependent Enzyme-Catalysed Intermolecular [4+2] Cycloaddition in Natural Product Biosynthesis" Nature Chemistry, 2020, 1, 620-628
Weilong Liu, Benke Hong, Jin Wang, Xiaoguang Lei* “New Strategies in the Efficient Total Syntheses of Polycyclic Natural Products” Acc. Chem. Res. 2020, 53, 2569-2586
Yingjie Bai, Hiu C Lam, Xiaoguang Lei* “Dissecting Programmed Cell Death with Small Molecules” Acc. Chem. Res. 2020, 53, 1034-1045
Sourav Banerjee, Tiantian Wei, Jue Wang, Jenna J. Lee, Haydee L. Gutierrez, Owen Chapman, Sandra E. Wiley, Joshua E. Mayfield, Vasudha Tandon, Edwin F. Juarez, Lukas Chavez, Ruqi Liang, Robert L. Sah, Caitlin Costello, Jill P. Mesirov, Laureano de la Vega, Kimberly L. Cooper, Jack E. Dixon*, Junyu Xiao*, and Xiaoguang Lei* “Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression” Proc. Natl Acad. Sci. USA 2019, 116, 24881-24891
Alexander X. Jones, Yong Cao, Yu-Liang Tang, Jian-Hua Wang, Yue-He Ding, Hui Tan, Zhen-Lin Chen, Run-Qian Fang, Jili Yin, Rong-Chang Chen, Xing Zhu, Yang She, Niu Huang, Feng Shao , Keqiong Ye , Rui-Xiang Sun, Si-Min He , Xiaoguang Lei* & Meng-Qiu Dong* “Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linker” Nature Comm. 2019, 10, 3911
Benke Hong, Weilong Liu, Jin Wang, Jinbao Wu, Yuichiro Kadonaga, Pei-Jun Cai, Hong-Xiang Lou, Zhixiang Yu, Houhua Li*, Xiaoguang Lei* “Photoinduced Skeletal Rearrangements Reveal Radical-Mediated Synthesis of Terpenoids” Chem 2019, 6, 1671-1681
