Long-term commitment to tumor molecular biology and tumor translational medicine research, focusing on the major basic issues of cell cycle and cell fate determination, focusing on spindle assembly protein machinery and cell division checkpoints, non-coding RNA, organelle communication and other directions. At the same time, he is committed to the research of gastrointestinal tumors, especially the molecular mechanism and diagnosis and treatment targets of the high incidence of esophageal squamous cell carcinoma in my country.
Internationally, it is the first to discover and systematically clarify the biological function and regulation mechanism of cell cycle checkpoints, revealing from a deep level the mechanism of abnormal cell cycle regulation leading to cell carcinogenesis. The first report on the genomic mutation of esophageal cancer in the world, comprehensively and systematically reveals the important gene mutations, copy number changes and gene structure mutations in the occurrence and development of esophageal cancer, providing a rich theoretical basis for early tumor diagnosis, screening drug targets, and optimizing clinical treatment And experimental basis. He has published more than 240 SCI academic papers, SCI has cited more than 14,000 times, and edited 7 books.
Song, Yongmei et al. Identification of genomic alterations in oesophageal squamous cell cancer. Nature. 2014;509:91-95.
Li, Dan et al. Long Noncoding RNA HULC Modulates the Phosphorylation of YB-1 Through Serving as a Scaffold of Extracellular Signal_x0002_Regulated Kinase and YB-1 to Enhance Hepatocarcinogenesis. Hepatology. 2017;65:1612-1627.
Wu, Qingnan et al. APC/C-CDH1-Regulated IDH3beta Coordinates with the Cell Cycle to Promote Cell Proliferation. Cancer Research. 2019;79:3281-93.
Yan, Ting et al. Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma. Nature Communications. 2019;10(1): 1670.
Li, Xianfeng et al. OncoBase: a platform for decoding regulatory somatic mutations in human cancers. Nucleic Acids Res. 2019;47:D1044-D1055.