Team Overview

With the notion of science above everything else, a strong tumor research team has been formed, combined with the academic background and interests of the scientists, and concentrated on tackling key tumor science and clinical core issues.

Changzheng Lu

Junior Principal Investigator

Research Areas

Lu lab focuses on the mechanisms of infiltration, survival and exhaustion of T cells in tumor microenvironment, aiming to :

  • Develop pharmacological intervention to enhance anti-cancer immunotherapies;
  • Design novel tumor vaccines.


  • EACR Top 10 Cancer Research Publications in 2020
  • Merit Student of 2013/2014 and 2009/2010 school years in the Institute of Biophysics, Chinese Academy of Sciences
  • Excellent Student Cadre of 2009/2010 school year in Graduate University of Chinese Academy of Sciences

Pictorial View

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  • 2022 – Present
    Shenzhen Bay Laboratory    Junior Principal Investigator
  • 2016 – 2022
    UT Southwestern Medical Center   Postdoc
  • 2009 – 2016
    Institute of Biophysics, CAS   PhD
  • 2005 – 2009
    Jiangnan University   Bachelor


Dr. Lu started tumor immunology research in his PhD program when he took a collaborated project of developing innovative immunotherapies with Drs Yongjun Liu and Lixin Li from Seven & Eight Biopharma. Currently, the project has entered phase II clinical trial in US. During his postdoc training, one of Dr Lu’s work has been published as two research articles back-on-back in Cancer Cell, which discovers the mechanisms of responsiveness and non-responsiveness in anti-PD1 therapy against dMMR tumor and reveals the key role of tumor cells-intrinsic cGAS-STING pathway in the tumor-infiltrating of T cells. This work is highly evaluated by the scientific community, especially by Professors Andrés Cervantes (president of ESMO) and Alberto Bardelli ( president of EACR), and elected as “EACR TOP 10 Cancer Research Publications” in 2020.

Selected Publications

Lu, C., Guan, J., Lu, S., Jin, Q., Rousseau, B., Lu, T., ... & Fu, Y. X. (2021). DNA sensing in mismatch repair-deficient tumor cells is essential for anti-tumor immunity. Cancer Cell, 39(1), 96-108.

This paper is previewed by Cancer Cell (; Highlighted by Science Signaling (; A highly cited paper by Web of Science.

Guan, J.#, Lu, C.#, Jin, Q., Lu, H., Chen, X., Tian, L., ... & Li, G. M. (2021). MLH1 deficiency-triggered DNA hyperexcision by exonuclease 1 activates the cGAS-STING pathway. Cancer Cell, 39(1), 109-121. A highly cited paper by Web of Science.

Zhang, A., Ren, Z., Tseng, K. F., Liu, X., Li, H., Lu, C., ... & Fu, Y. X. (2021). Dual targeting of CTLA-4 and CD47 on Treg cells promotes immunity against solid tumors. Science Translational Medicine, 13(605), eabg8693.

Suresh, S., Chen, B., Zhu, J., Golden, R. J., Lu, C., Evers, B. M., ... & O’Donnell, K. A. (2020). eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer. Nature Cancer, 1(5), 533-545.

Li, H. D., Lu, C., Zhang, H., Hu, Q., Zhang, J., Cuevas, I. C., ... & Castrillon, D. H. (2020). A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response. JCI insight, 5(14).