Lu lab focuses on the mechanisms of infiltration, survival and exhaustion of T cells in tumor microenvironment, aiming to :
Lu, C., Guan, J., Lu, S., Jin, Q., Rousseau, B., Lu, T., ... & Fu, Y. X. (2021). DNA sensing in mismatch repair-deficient tumor cells is essential for anti-tumor immunity. Cancer Cell, 39(1), 96-108.
This paper is previewed by Cancer Cell (https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30664-4); Highlighted by Science Signaling (https://stke.sciencemag.org/content/14/666/eabg5661.full); A highly cited paper by Web of Science.
Guan, J.#, Lu, C.#, Jin, Q., Lu, H., Chen, X., Tian, L., ... & Li, G. M. (2021). MLH1 deficiency-triggered DNA hyperexcision by exonuclease 1 activates the cGAS-STING pathway. Cancer Cell, 39(1), 109-121. A highly cited paper by Web of Science.
Zhang, A., Ren, Z., Tseng, K. F., Liu, X., Li, H., Lu, C., ... & Fu, Y. X. (2021). Dual targeting of CTLA-4 and CD47 on Treg cells promotes immunity against solid tumors. Science Translational Medicine, 13(605), eabg8693.
Suresh, S., Chen, B., Zhu, J., Golden, R. J., Lu, C., Evers, B. M., ... & O’Donnell, K. A. (2020). eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer. Nature Cancer, 1(5), 533-545.
Li, H. D., Lu, C., Zhang, H., Hu, Q., Zhang, J., Cuevas, I. C., ... & Castrillon, D. H. (2020). A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response. JCI insight, 5(14).